Non-genetic resistance facilitates survival while hindering the evolution of drug resistance due to intraspecific competition.

doi:10.1088/1478-3975/ac8c17

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Article

Non-genetic resistance facilitates survival while hindering the evolution of drug resistance due to intraspecific competition.

Physical biology - 8 Sept 2022

Guthrie Joshua D, Charlebois Daniel A

Abstract excerpt

Rising rates of resistance to antimicrobial drugs threaten the effective treatment of infections across the globe. Drug resistance has been established to emerge from non-genetic mechanisms as well as from genetic mechanisms. However, it is still unclear how non-genetic resistance affects the evolution of genetic drug resistance. We develop deterministic and stochastic population models that incorporate resource...

Topics

Drug Resistance
Humans
Mutation
Population Dynamics
Probability

Source

Open in PubMed

Identifiers

PMID: 35998624
DOI: 10.1088/1478-3975/ac8c17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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