Article

Diverse mutant selection windows shape spatial heterogeneity in evolving populations

2023-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Mutant selection windows (MSWs), the range of drug concentrations that select for drug-resistant mutants, have long been used as a model for predicting drug resistance and designing optimal dosing strategies in infectious disease. The canonical MSW model offers comparisons between two subtypes at a time: drug-sensitive and drug-resistant. In contrast, the fitness landscape model with N alleles,...

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Literature Corpus work: b7d0c677-ca66-5d09-9e59-7f4d7fdbb1be
DOI: 10.1101/2023.03.09.531899

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