Article

Evolutionary rescue is promoted in compact cellular populations

2022-05-28

Abstract excerpt

Mutation-mediated drug resistance is one of the primary causes for the failure of modern antibiotic or chemotherapeutic treatment. Yet, in the absence of treatment many drug resistance mutations are associated with a fitness cost and therefore subject to purifying selection. While, in principle, resistant subclones can escape purifying selection via subsequent compensatory mutations, current models predict such ev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61ae7f7f-f4a3-5f83-8fd0-030ed8c10069
DOI: 10.1101/2022.05.27.493727

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary rescue is promoted in compact cellular populationsDOI 10.1101/2022.05.27.493727Read

Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.Semantic proximity Read

Excess of mutational jackpot events in growing populations due to gene surfingSemantic proximity Read

Excess of mutational jackpot events in expanding populations revealed by spatial Luria-Delbrück experiments.Semantic proximity Read

Range expansion shifts clonal interference patterns in evolving populationsSemantic proximity Read

Range expansion shifts clonal interference patterns in evolving populationsSemantic proximity Read

Spatial population structure can reverse the dependence of mutant burden on the death-to-birth ratio of cellsSemantic proximity Read

Impact of crowding on the diversity of expanding populations.Semantic proximity Read

Drug-induced resistance evolution necessitates less aggressive treatment.Semantic proximity Read

Drug-induced resistance evolution necessitates less aggressive treatmentSemantic proximity Read

Frequency-dependent ecological interactions increase the prevalence, and shape the distribution, of pre-existing drug resistanceSemantic proximity Read

Determinants of Genetic Diversity of Spontaneous Drug Resistance in Bacteria.Semantic proximity Read

Mutational pathway determines whether drug gradients accelerate evolution of drug-resistant cells.Semantic proximity Read