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Article

Tuning Spatial Profiles of Selection Pressure to Modulate the Evolution of Drug Resistance.

Physical review letters - 8 Jun 2018

De Jong Maxwell G, Wood Kevin B

Abstract excerpt

Spatial heterogeneity plays an important role in the evolution of drug resistance. While recent studies have indicated that spatial gradients of selection pressure can accelerate resistance evolution, much less is known about evolution in more complex spatial profiles. Here we use a stochastic toy model of drug resistance to investigate how different spatial profiles of selection pressure impact the time to...

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Identifiers

PMID: 29932692
DOI: 10.1103/PhysRevLett.120.238102
PMCID: PMC6029889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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