Article

The Fitness Cost of Therapeutic Resistance in Cancer: A Systematic Review

2025-12-31

Abstract excerpt

Emergence of therapeutic resistance is a critical clinical challenge in cancer treatment, contributing to treatment failure, disease relapse, and patient mortality. Prior to treatment initiation, therapy-resistant clones typically make up such a small proportion of the neoplasm that they can be hard to detect and only expand under the selective pressure of therapy. This suggests that resistant clones incur a fitne...

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Literature Corpus work: f2c14d5d-a665-59f8-bcc1-82359c374655
DOI: 10.64898/2025.12.29.696883

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