Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment

10 Apr 2019

Abstract excerpt

PURPOSE: Drug resistance is a major impediment to the success of cancer treatment. Resistance is typically thought to arise from random genetic mutations, after which mutated cells expand via Darwinian selection. However, recent experimental evidence suggests that progression to drug resistance need not occur randomly, but instead may be induced by the treatment itself via either genetic changes or epigenetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Mathematical Biology Tumor Growth

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30969799
DOI: 10.1200/cci.18.00087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer TreatmentPMID 30969799Read ↗

Understanding the role of phenotypic switching in cancer drug resistance.Semantic proximity Read ↗

Drug resistance in cancer mechanisms and modelsSemantic proximity Read ↗

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration StrategiesSemantic proximity Read ↗

Stochastic modeling of drug resistance in cancer.Semantic proximity Read ↗

Evolutionary rescue model informs strategies for driving cancer cell populations to extinctionSemantic proximity Read ↗

Drug-induced resistance evolution necessitates less aggressive treatmentSemantic proximity Read ↗

Mathematical Model of Intrinsic Drug Resistance in Lung Cancer.Semantic proximity Read ↗

Drug resistance in cancer: Principles of emergence and preventionSemantic proximity Read ↗

Genetic and non‐genetic drug resistance: Darwin or Lamarck?Semantic proximity Read ↗

Circumventing Cancer Drug Resistance in the Era of Personalized MedicineSemantic proximity Read ↗

Probability of resistance evolution for exponentially growing virus in the host.Semantic proximity Read ↗

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.