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Article

A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax.

Malaria journal - 25 Jan 2016

Ogbunugafor C Brandon, Hartl Daniel

Abstract excerpt

BACKGROUND: The study of reverse evolution from resistant to susceptible phenotypes can reveal constraints on biological evolution, a topic for which evolutionary theory has relatively few general principles. The public health catastrophe of antimicrobial resistance in malaria has brought these constraints on evolution into a practical realm, with one proposed solution: withdrawing anti-malarial medication use in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26809718
DOI: 10.1186/s12936-016-1090-3
PMCID: PMC4727274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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