A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax.

doi:10.1186/s12936-016-1090-3

Back to search

Article

A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax.

Malaria journal - 25 Jan 2016

Ogbunugafor C Brandon, Hartl Daniel

Abstract excerpt

BACKGROUND: The study of reverse evolution from resistant to susceptible phenotypes can reveal constraints on biological evolution, a topic for which evolutionary theory has relatively few general principles. The public health catastrophe of antimicrobial resistance in malaria has brought these c...

Topics

Antimalarials
Biological Evolution
Drug Resistance
Mutation
Plasmodium vivax
Protozoan Proteins
Pyrimethamine
Tetrahydrofolate Dehydrogenase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.