Article

A Specialized Centrosome-Proteasome Axis Mediates Proteostasis and Influences Cardiac Stress through Txlnb

2024-02-14

Abstract excerpt

<h4>Background</h4> Centrosomes localize to perinuclear foci where they serve multifunctional roles, arranging the microtubule organizing center (MTOC) and anchoring ubiquitin-proteasome system (UPS) machinery. In mature cardiomyocytes, centrosomal proteins redistribute into a specialized perinuclear cage-like structure, and a potential centrosome-UPS interface has not been studied. Taxilin-beta (Txlnb), a cardio...

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Literature Corpus work: 62d42539-f02d-5c38-916c-818f672c606b
DOI: 10.1101/2024.02.12.580020

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