Article

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult Heart

2025-12-07

Abstract excerpt

<h4>BACKGROUND</h4> Disruption of mitochondrial homeostasis drives cardiomyopathy and heart failure, yet upstream regulatory mechanisms remain poorly defined. Neddylation, a reversible post-translational conjugation of the ubiquitin-like protein NEDD8 by E1/E2/E3 enzymes, is essential for cardiac morphogenesis, but its role in the adult heart is unknown. <h4>METHODS</h4> We assessed the relevance of neddylation...

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Literature Corpus work: 4a637ae0-eb7b-5e09-8f0b-4e71d5b8eb2c
DOI: 10.64898/2025.12.03.692150

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