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Article

Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.

PLoS genetics - 1 Sept 2017

Kennedy Leslie, Kaltenbrun Erin, Greco Todd M, Temple Brenda, Herring Laura E, Cristea Ileana M, Conlon Frank L

Abstract excerpt

By the age of 40, one in five adults without symptoms of cardiovascular disease are at risk for developing congestive heart failure. Within this population, dilated cardiomyopathy (DCM) remains one of the leading causes of disease and death, with nearly half of cases genetically determined. Though genetic and high throughput sequencing-based approaches have identified sporadic and inherited mutations in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28945738
DOI: 10.1371/journal.pgen.1007011
PMCID: PMC5629033

Genes

TBX20
CASZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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