Article

Chronic activation of tubulin tyrosination in HCM mice and in human iPSC-engineered heart tissues improves heart function

2023-05-28

Abstract excerpt

<h4>Rationale</h4> Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder caused by sarcomeric gene variants and associated with left ventricular (LV) hypertrophy and diastolic dysfunction. The role of the microtubule network has recently gained interest with the findings that α-tubulin detyrosination (dTyr-tub) is markedly elevated in heart failure. Acute reduction of dTyr-tub by inhibitio...

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Literature Corpus work: ec5a178f-8e14-5522-be08-2e490e78330d
DOI: 10.1101/2023.05.25.542365

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