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Article

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function

14 Nov 2011

Abstract excerpt

Human mutations in or variants of TBX20 are associated with congenital heart disease, cardiomyopathy, and arrhythmias. To investigate whether cardiac disease in patients with these conditions results from an embryonic or ongoing requirement for Tbx20 in myocardium, we ablated Tbx20 specifically in adult cardiomyocytes in mice. This ablation resulted in the onset of severe cardiomyopathy accompanied by...

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PMID: 22080862
DOI: 10.1172/jci59472

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