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TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure

11 Jun 2024

Abstract excerpt

BACKGROUND: The tumor suppressor and proapoptotic transcription factor P53 is induced (and activated) in several forms of heart failure, including cardiotoxicity and dilated cardiomyopathy; however, the precise mechanism that coordinates its induction with accessibility to its transcriptional promoter sites remains unresolved, especially in the setting of mature terminally differentiated (nonreplicative)...

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PMID: 38860363
DOI: 10.1161/circresaha.123.324202

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