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Article

Emerging Role of TRIM Family Proteins in Cardiovascular Disease

1 Jan 2020

Abstract excerpt

Ubiquitination is one of the basic mechanisms of cell protein homeostasis and degradation and is accomplished by 3 enzymes, E1, E2, and E3. Tripartite motif-containing proteins (TRIMs) constitute the largest subfamily of RING E3 ligases, with >70 current members in humans and mice. These members are involved in multiple biological processes, including growth, differentiation, and apoptosis as well as disease and...

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PMID: 32305978
DOI: 10.1159/000506150

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