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Article

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to <i>LMNA</i> cardiomyopathy

2023-02-14

Abstract excerpt

Mutations in the LMNA gene encoding nuclear lamins A/C cause a diverse array of tissue-selective diseases, with the heart being the most commonly affected organ. Despite progress in understanding the molecular perturbations emanating from LMNA mutations, an integrative understanding of the pathogenesis leading to cardiac dysfunction remains elusive. Using a novel cell-type specific Lmna deletion mouse model cap...

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Literature Corpus work
11b68e8e-d20b-56b7-b9ad-1b26dce09ede
DOI
10.1101/2023.02.14.528563
Open publication

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Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to <i>LMNA</i> cardiomyopathyDOI 10.1101/2023.02.14.528563
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