Article

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

2024-11-26

Abstract excerpt

<h4>Background</h4> Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, and mutations in PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) and BAG3 (proline to lysine at position 209, P209L) induce protein aggregate pathology with cardiomyopathy in humans. Novel observations in yeast and mammalian cells demonstrate mitochon...

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Literature Corpus work: 3bb5f6f6-d40b-59a5-924b-1e0807dc642f
DOI: 10.1101/2024.11.24.624947

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