Article

Knockout of Sorbs2 in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice

2022-02-13

Abstract excerpt

2. <h4>Rationale</h4> Sorbs2 is a cardiomyocyte-enriched, cytoskeletal adaptor protein, and given some evidence for its dysregulated expression in failing hearts, there is growing interest in understanding its roles in cardiac biology and disease. While Sorbs2 global knockout mice display lethal cardiomyopathy with severe arrhythmias, the underlying mechanisms remain unclear, and whether this results from intrins...

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Literature Corpus work: b5638782-69b9-51d4-9fb5-09271563f3bb
DOI: 10.1101/2022.02.13.480093

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