Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy

Abstract excerpt

Background: During cardiomyocyte maturation, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization where its components reorganize from being localized at the centriole to the nuclear envelope. This developmentally programmed process, referred to as centrosome reduction, has been previously associated with cell cycle exit. However,...

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