Article

Promoter-specific changes in initiation, elongation and homeostasis of histone H3 acetylation during CBP/p300 Inhibition

2020-09-27

Abstract excerpt

<h4>Summary</h4> Regulation of RNA Polymerase II (Pol2) elongation in the promoter proximal region is an important and ubiquitous control point for gene expression in metazoan cells. We report that transcription of the adenovirus 5 E4 region is regulated during the release of paused Pol2 into productive elongation by recruitment of the super elongation complex (SEC), dependent on promoter H3K18/27 acetylation by...

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Literature Corpus work: 62c2f9e4-fc76-5d8e-b3c9-91e4cedf8dea
DOI: 10.1101/2020.09.26.315002

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