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Article

DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2020

Basu Subham, Barad Mahesh, Yadav Dipika, Nandy Arijit, Mukherjee Bidisha, Sarkar Jit, Chakrabarti Partha, Mukhopadhyay Satinath, Biswas Debabrata

Abstract excerpt

Among all of the Super Elongation Complex (SEC) components, ELL1 (also known as ELL) is the only bona fide elongation factor that directly stimulates transcription elongation by RNA polymerase II. However, the mechanism(s) of functional regulation of ELL1 (referred to as ELL hereafter), through its stabilization, is completely unknown. Here, we report a function of human DBC1 in regulating ELL stability involving...

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Share to Acetylation
Share to E1A-Associated p300 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Histone Deacetylases

Share to Leukocytes, Mononuclear

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Identifiers

PMID: 32152128
DOI: 10.1073/pnas.1912375117
PMCID: PMC7104407

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