Article
Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.
The Journal of biological chemistry - 1 Sept 2017
Gates Leah A, Shi Jiejun, Rohira Aarti D, Feng Qin, Zhu Bokai, Bedford Mark T, Sagum Cari A, Jung Sung Yun, Qin Jun, Tsai Ming-Jer, Tsai Sophia Y, Li Wei, Foulds Charles E, O'Malley Bert W
Abstract excerpt
The transition from transcription initiation to elongation is a key regulatory step in gene expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing on chromatin. Although elongation factors promote pause release leading to transcription elongation, the role of epigenetic modifications during this critical transition step is poorly understood. Two histone marks on histone H3,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.