Article

Alzheimer’s Disease Heterogeneity Explained by Polygenic Risk Scores Derived from Brain Transcriptomic Profiles

2022-12-21

Abstract excerpt

<h4>INTRODUCTION</h4> Alzheimer’s disease (AD) is heterogeneous, both clinically and neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with transcriptome profiles from AD brains can explain AD clinical heterogeneity. <h4>METHODS</h4> We conducted co-expression analysis and identified gene-sets (modules) which were preserved in three AD transcriptome datasets and associated with A...

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Literature Corpus work: 62be9a4c-4b8f-59a7-b55e-476fcc190f02
DOI: 10.1101/2022.12.20.22283737

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