Article

Dissecting Alzheimer’s disease heterogeneity by cross-trait polygenic prediction

2026-05-15

Abstract excerpt

Mapping the genetic basis of inter-individual heterogeneity in multifactorial diseases opens the door to mechanistic insights and opportunities for targeted intervention. In Alzheimer’s disease (AD), clinical and pathological heterogeneity is well recognized, but genetic dissection is limited by a lack of well-powered cohorts with deep phenotypic characterization. Here, we introduce a polygenic score (PGS) analysi...

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Literature Corpus work: 3019343c-9d98-50bd-801d-31ec21b801af
DOI: 10.64898/2026.05.15.725551

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