Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles

11 May 2023

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is heterogeneous, both clinically and neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with transcriptome profiles from AD brains can explain AD clinical heterogeneity. METHODS: We conducted co-expression network analysis and identified gene sets (modules) that were preserved in three AD transcriptome datasets and associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37166019
DOI: 10.1002/alz.13069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profilesPMID 37166019Read ↗

Alzheimer’s Disease Heterogeneity Explained by Polygenic Risk Scores Derived from Brain Transcriptomic ProfilesSemantic proximity Read ↗

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read ↗

Transcriptomic Stratification of Late-Onset Alzheimer’s Cases Reveals Novel Genetic Modifiers of Disease PathologySemantic proximity Read ↗

Dissecting Alzheimer’s disease heterogeneity by cross-trait polygenic predictionSemantic proximity Read ↗

An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease.Semantic proximity Read ↗

Exploring the Genetic Heterogeneity of Alzheimer's Disease: Evidence for Genetic Subtypes.Semantic proximity Read ↗

Exploring the genetic heterogeneity of Alzheimer’s disease: Evidence for genetic subtypesSemantic proximity Read ↗

Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology.Semantic proximity Read ↗

Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read ↗

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers.Semantic proximity Read ↗

Analysis of Alzheimer’s disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.