Article

Single cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predisposition

2024-11-19

Abstract excerpt

Inherited genetic variants contribute to Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) but it is unknown which cell types are involved in this process. We performed single cell RNA-sequencing of BE, EAC and paired normal tissues and integrated data of a genome-wide association study to determine cell type-specific genetic risk and cellular processes that contribute to BE and EAC. The analysis reveal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40f71a1d-9fdc-5b40-89c7-45a178512aa2
DOI: 10.1101/2024.11.18.624112

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell analysis of Barrett’s esophagus and carcinoma reveals cell types conferring risk via genetic predispositionDOI 10.1101/2024.11.18.624112Read

Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.Semantic proximity Read

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” eraSemantic proximity Read

Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing.Semantic proximity Read

Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal EvolutionSemantic proximity Read

Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysisSemantic proximity Read

The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read

Deciphering Precursor Cell Dynamics in Esophageal Preneoplasia via Genetic Barcoding and Single-Cell TranscriptomicsSemantic proximity Read

Molecular characterization of Barrett's esophagus at single-cell resolution.Semantic proximity Read

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysisSemantic proximity Read

Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric CancerSemantic proximity Read

Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.Semantic proximity Read

A comprehensive analysis of single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancerSemantic proximity Read