Article

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

2022-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Although Barrett’s metaplasia of the esophagus (BE) is the only known precursor lesion to esophageal adenocarcinomas (EACs), drivers of the metaplasia→dysplasia→neoplasia cascade in the esophagus remains incompletely understood. Using an AI-guided network transcriptomics approach, in which EAC initiation and progression is modeled as networks to simplify complex multi-cellular processes, we firs...

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Literature Corpus work: 1be4a234-ad08-58da-ac50-b2051338c5e1
DOI: 10.1101/2022.01.30.478408

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