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Article

Single-cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition.

Cell genomics - 8 Oct 2025

Wenzel Marten C, Dasmeh Pouria, Plum Patrick S, Giel Ann-Sophie, Hoppe Sascha, Franitza Marek, Jonas Christoph, Thieme René, Zhao Yue, Heider Dominik, Palles Claire, Fitzgerald Rebecca Claire, Bruns Christiane J, Buettner Reinhard, Quaas Alexander, Gockel Ines, Maj Carlo, Chon Seung-Hun, Schumacher Johannes, Hillmer Axel M

Abstract excerpt

Inherited genetic variants contribute to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), but it is unknown which cell types are involved in this process. We performed single-cell RNA sequencing of BE, EAC, and paired normal tissues and integrated genome-wide association data to determine cell-type-specific genetic risk and cellular processes that contribute to BE and EAC. The analysis reveals that...

Read the complete abstract on PubMed

Topics

Humans
Barrett Esophagus
Esophageal Neoplasms
Single-Cell Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Adenocarcinoma

Genome-Wide Association Study

Fibroblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 40925382
DOI: 10.1016/j.xgen.2025.100980
PMCID: PMC12790991

Genes

CD4

Provenance

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