Article

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

2024-08-19

Abstract excerpt

Esophageal adenocarcinoma (EAC) is a highly lethal cancer of the upper gastrointestinal tract with rising incidence in western populations. To decipher EAC disease progression and therapeutic response, we performed multiomic analyses of a cohort of primary and metastatic EAC tumors, incorporating single-nuclei transcriptomic and chromatin accessibility sequencing, along with spatial profiling. We identified tumor...

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Literature Corpus work: 43b4449e-25cd-5395-be66-c615a484c38e
DOI: 10.1101/2024.08.17.608386

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