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Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

1 Mar 2025

Abstract excerpt

Cancer development involves the co-evolution of cancer cells and their surrounding microenvironment, yet the dynamics of this interaction within the physical architecture remains poorly understood. Here, we present a spatial transcriptomic map at single-cell resolution, encompassing 127 multi-stage fields of view from 43 patients, to chart the evolutionary trajectories of human esophageal squamous cell carcinoma...

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PMID: 40068596
DOI: 10.1016/j.ccell.2025.02.009

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