Article

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

2024-11-18

Abstract excerpt

Somatic mitochondrial DNA (mtDNA) mutations are heavily implicated as important drivers of ageing and age-related diseases. Their pathological effect can be partially counteracted by increasing the absolute amount of wild-type mtDNA via moderately upregulating TFAM, a protein important for mtDNA packaging and expression. However, strong TFAM overexpression can also have detrimental effects as it results in hyperco...

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Literature Corpus work: 626f5008-c261-584b-a7b2-1ea103015350
DOI: 10.1101/2024.11.14.623694

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