Article

Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species

2023-07-04

Abstract excerpt

Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA (mtDNA) mutation rates show accelerated ageing. A scarcely studied aspect of ageing, because it is invisible in aggregate analyses, is the accumulation of somatic mtDNA mutations which are unique to single cells (cryptic mu...

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Literature Corpus work: 28817292-253d-59e5-8bdb-801ee5699f2b
DOI: 10.1101/2023.07.04.547509

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