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Article

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

29 Jun 2015

Abstract excerpt

Mitochondria are highly adaptable organelles that can facilitate communication between tissues to meet the energetic demands of the organism. However, the mechanisms by which mitochondria can nonautonomously relay stress signals remain poorly understood. Here we report that mitochondrial mutations in the young, preprogeroid polymerase gamma mutator (POLG) mouse produce a metabolic state of starvation. As a...

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PMID: 26124126
DOI: 10.1073/pnas.1509930112

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