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Article

TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction

27 Jul 2021

Abstract excerpt

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfamfl/fl UBC-Cre/ERT2+/+ mice to investigate mitochondrial dysfunction in the stromal cell component, we describe an inducible in vitro model...

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PMID: 34312668
DOI: 10.1242/dmm.048995

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