Article
Mitochondrial DNA and ageing.
Biochimica et biophysica acta - 1 Jan 2000
Trifunovic Aleksandra
Abstract excerpt
The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing. Recently, considerable progress in understanding basic mitochondrial...
Topics
- Aging
- Animals
- DNA, Mitochondrial
- Humans
- Mice
- Mitochondrial Diseases
- Mutation