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Mitochondrial transcription factor A regulates mtDNA copy number in mammals

3 Mar 2004

Abstract excerpt

Mitochondrial DNA (mtDNA) copy number regulation is altered in several human mtDNA-mutation diseases and it is also important in a variety of normal physiological processes. Mitochondrial transcription factor A (TFAM) is essential for human mtDNA transcription and we demonstrate here that it is also a key regulator of mtDNA copy number. We initially performed in vitro transcription studies and determined that the...

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PMID: 15016765
DOI: 10.1093/hmg/ddh109

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