Article

Quantitative biochemical profiling of GCase activity and α-synuclein proteoforms in postmortem human brains from GBA-related and idiopathic Parkinson’s disease

2026-04-10

Abstract excerpt

<title>Abstract</title> <p> Parkinson’s disease (PD) is characterized by α-synuclein (αSyn) deposition and lysosomal dysfunction. Variants in the <italic>GBA1</italic> gene, which encodes for lysosomal glucocerebrosidase (GCase), are PD risk factors (GBA-PD) and have been associated with increased cortical involvement compared to idiopathic PD (IPD). Nonetheless, the relationship between αSyn accumulation and...

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Literature Corpus work: 624b684b-80f0-52ac-a6c2-9f36a4b86115
DOI: 10.21203/rs.3.rs-9264325/v1

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