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Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

11 May 2023

Abstract excerpt

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rare genetic mutations that cause disease and more common variants that increase incidence of disease. The most prominent genetic mutations for PD and DLB are in the GBA1 and LRRK2...

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PMID: 37169750
DOI: 10.1038/s41531-023-00517-w

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