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Article

Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation.

Brain : a journal of neurology - 13 May 2025

Lado Wudu, Ham Ahrom, Li Hongyu, Zhang Hong, Chang Audrey Yuen, Sardi Sergio Pablo, Alcalay Roy N, Arancio Ottavio, Przedborski Serge, Tang Guomei

Abstract excerpt

Cognitive impairment is a common but poorly understood non-motor aspect of Parkinson's disease, negatively affecting the patient's functional capacity and quality of life. The mechanisms underlying cognitive impairment in Parkinson's disease remain elusive, limiting treatment and prevention strategies. This study investigates the molecular and cellular basis of cognitive impairment associated with heterozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39562000
DOI: 10.1093/brain/awae380
PMCID: PMC12073992

Genes

GBA1
CA1
CA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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