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Article

Advances in GBA-associated Parkinson's disease--Pathology, presentation and therapies.

Neurochemistry international - 1 Feb 2016

Barkhuizen Melinda, Anderson David G, Grobler Anne F

Abstract excerpt

GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and bi-allelic mutations confer risk for Parkinson's disease. Clinically, Parkinson's disease patients with GBA mutations resemble idiopathic Parkinson's disease patients. However, these patients have...

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PMID: 26743617
DOI: 10.1016/j.neuint.2015.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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