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Article

The interplay between Glucocerebrosidase, α-synuclein and lipids in human models of Parkinson’s disease

25 Dec 2020

Abstract excerpt

Mutations in the gene GBA, encoding glucocerebrosidase (GCase), are the highest genetic risk factor for Parkinson's disease (PD). GCase is a lysosomal glycoprotein responsible for the hydrolysis of glucosylceramide into glucose and ceramide. Mutations in GBA cause a decrease in GCase activity, stability and protein levels which in turn lead to the accumulation of GCase lipid substrates as well as α-synuclein (αS)...

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PMID: 33832803
DOI: 10.1016/j.bpc.2020.106534

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