Article

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

2022-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rare genetic mutations that cause disease and more common variants that increase incidence of disease. The most prominent genetic mutations for PD and DLB are in t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fe59714-f959-54be-b653-b0a5b7aa63b6
DOI: 10.1101/2022.11.11.516171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseDOI 10.1101/2022.11.11.516171Read

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseSemantic proximity Read

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.Semantic proximity Read

The interplay between Glucocerebrosidase, α-synuclein and lipids in human models of Parkinson’s diseaseSemantic proximity Read

The role of glucocerebrosidase in Parkinson disease pathogenesis.Semantic proximity Read

Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.Semantic proximity Read

Quantitative biochemical profiling of GCase activity and α-synuclein proteoforms in postmortem human brains from GBA-related and idiopathic Parkinson’s diseaseSemantic proximity Read

Glucocerebrosidase and Parkinson disease: Recent advances.Semantic proximity Read

Glucocerebrosidase Mutations Cause Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease: Pathogenesis and Therapeutic ImplicationsSemantic proximity Read

GBA mutations, glucosylceramide and Parkinson's disease.Semantic proximity Read

Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease.Semantic proximity Read

Multi-omics insights into GBA1-associated Parkinson's disease: interplay of genomics, transcriptomics, proteomics, and lipidomics.Semantic proximity Read

Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatmentSemantic proximity Read