Article

CSF glucosylsphingosine is a central readout of GCase impairment across genetic and sporadic Parkinson’s disease

2026-06-22

Abstract excerpt

Parkinson’s disease (PD) risk converges on lysosomal biology, including reduced activity of glucocerebrosidase (GCase), encoded by GBA1 . Glucosylsphingosine (GlcSph), a toxic deacylated glycosphingolipid and established target engagement biomarker in Gaucher disease, is difficult to quantify in cerebrospinal fluid (CSF) because of low abundance and isomeric interference. We optimized and qualified targeted LC–MS...

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Literature Corpus work: f8438cd7-9f5b-5f90-afcd-0fa336c26180
DOI: 10.64898/2026.06.19.733447

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