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Article

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.

Brain : a journal of neurology - 1 Mar 2014

Murphy Karen E, Gysbers Amanda M, Abbott Sarah K, Tayebi Nahid, Kim Woojin S, Sidransky Ellen, Cooper Antony, Garner Brett, Halliday Glenda M

Abstract excerpt

Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are the most frequent known genetic risk factor for Parkinson's disease. Reduced glucocerebrosidase and α-synuclein accumulation are directly related in cell models of Parkinson's disease. We investigated relationships between Parkinson's disease-specific glucocerebrosidase deficits, glucocerebrosidase-related pathways, and...

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Source

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Identifiers

PMID: 24477431
DOI: 10.1093/brain/awt367
PMCID: PMC3927701

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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