Differential Functions of Splicing Factors in Breast-Cancer Initiation and Metastasis

Abstract excerpt

<h4>SUMMARY</h4> Misregulation of alternative splicing is a hallmark of human tumors; yet to what extent and how it contributes to malignancy are only beginning to be unraveled. Here, we define which members of the splicing factor SR and SR-like families contribute to breast cancer, and uncover differences and redundancies in their targets and biological functions. We first identify splicing factors frequently al...

Topics

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• Alternative Splicing
• Bayes Theorem
• Cell Culture Techniques
• Gene Regulatory Networks
• HeLa Cells
• RNA Splice Sites
• Sequence Analysis, RNA
• Serine-Arginine Splicing Factors

Identifiers and source

Literature Corpus work

6235fb89-d483-5e77-8027-2a612a9f8edc

DOI

10.1101/634154