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Article

RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation.

Carcinogenesis - 1 Nov 2013

Shimoni-Sebag Ariel, Lebenthal-Loinger Ilana, Zender Lars, Karni Rotem

Abstract excerpt

Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have shown previously that the splicing factor serine and arginine splicing factor 1 (SRSF1; SF2/ASF) is...

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Source

Identifiers

PMID: 23843040
DOI: 10.1093/carcin/bgt247

Genes

SRSF1
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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