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Article

Aberrant RNA splicing and therapeutic opportunities in cancers.

Cancer science - 1 Feb 2022

Yamauchi Hirofumi, Nishimura Kazuki, Yoshimi Akihide

Abstract excerpt

There has been accumulating evidence that RNA splicing is frequently dysregulated in a variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 and U2AF1, are commonly enriched across cancers, strongly suggesting that aberrant RNA splicing is a new class of hallmark that contributes to the initiation and/or maintenance of cancers. In parallel, some studies have demonstrated that...

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PMID: 34812550
DOI: 10.1111/cas.15213
PMCID: PMC8819303

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