Article

<i>SRF</i> fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> SRF fusion genes drive the pathogenesis of muscle-related soft tissue tumors, including subsets of perivascular tumors, inflammatory myofibroblastic tumor, and rhabdomyosarcoma. SRF encodes Serum Response Factor, a well-characterized transcription factor that regulates muscle development. We characterized four fusion genes: SRF::RELA, SRF::FOXO1, SRF::ICA1L, and SRF::PDGFRB. All localized to the...

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Literature Corpus work: a0e87ea5-53af-5c1c-99a4-84f56da3ae0a
DOI: 10.1101/2025.09.18.676997

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