Article

Genome Organizer SATB1 selectively activates a defined subset of EMT genes driving metastatic breast cancer

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> SATB1 reshapes chromatin architecture and transcriptional programs to promote breast cancer metastasis. However, its key downstream effectors remain incompletely defined. Here, we aimed to identify actionable drivers of invasion by focusing on epithelial-mesenchymal transition (EMT) genes. We identified 98 of 300 curated EMT-promoting genes as direct SATB1 targets in human breast epithelial cell...

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Literature Corpus work: 6403bb33-52ea-54e8-bde6-7d7d9ae74824
DOI: 10.64898/2026.05.29.728584

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