Article

scRNA-seq and spatial transcriptomics reveal neuroendocrine-like cancer cells promote angiogenesis and EMT through neural signaling pathways in male breast cancer

2024-05-28

Abstract excerpt

<title>Abstract</title><p>Male breast cancer (MBC) is a relatively rare and inadequately researched disease, and its cellular and molecular traits remain obscure. In this study, we conducted single-cell sequencing (N=20) and spatial transcriptomics (N=14) on 34 fresh tissue samples from 27 MBC patients. We identified six major cancer cell subtypes that are associated with the development and progression of MBC. Sp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24d4cc0a-94a3-5a94-b7dc-dbf225761127
DOI: 10.21203/rs.3.rs-4291684/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

scRNA-seq and spatial transcriptomics reveal neuroendocrine-like cancer cells promote angiogenesis and EMT through neural signaling pathways in male breast cancerDOI 10.21203/rs.3.rs-4291684/v1Read

Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific EnhancersSemantic proximity Read

Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer.Semantic proximity Read

Single-Cell RNA and ATAC Sequencing Reveal Cellular Heterogeneity and Chromatin Accessibility Dynamics in Young Chinese Breast Cancer Patients across Pre- and Post-Neoadjuvant TherapySemantic proximity Read

Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signalingSemantic proximity Read

The Human Male Mammary Gland has Similar Epithelial Populations to Female but Distinct Composition and Transcriptional PropertiesSemantic proximity Read

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastasesSemantic proximity Read

Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancerSemantic proximity Read

The Genomic Landscape of Male Breast Cancers.Semantic proximity Read

A spatially resolved single cell genomic atlas of the adult human breastSemantic proximity Read

Clinicopathological and genetic analysis of 55 male patients with invasive breast cancerSemantic proximity Read

Migratory Tumor Cells Cooperate with Cancer Associated Fibroblasts in Hormone Receptor-Positive and HER2-Negative Breast CancerSemantic proximity Read

Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progressionSemantic proximity Read