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Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

1 Dec 2019

Abstract excerpt

Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult HSCs with distinct functional properties. To better understand the molecular mechanisms underlying the developmental switch, we have conducted deep sequencing of the 3D genome, epigenome, and transcriptome of fetal and adult HSCs in mouse. We find that chromosomal compartments and topologically associating domains (TADs) are...

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PMID: 31851943
DOI: 10.1016/j.celrep.2019.11.065

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